FXR-CNIO - Grupo de Patología Molecular
Centro de Investigaciones Oncológicas. CNIO
Group Leader: This email address is being protected from spambots. You need JavaScript enabled to view it.
AIMS
Our Group is interested in understanding the molecular/cellular mechanisms involved in pancreatic and bladder cancer and applying such knowledge at the clinical level.
We adopt a transversal approach and aim to address important questions through the biochemical or genetic analysis of genes/molecules involved in these tumours and later test the relevance of the findings in the clinical setting – often using mouse models as an intermediate step.
Alternatively, we make observations in molecular pathology/epidemiology studies and then test the mechanisms involved using in vitro and in vivo experimental systems.
Pancreatic cancer:
- Understand how changes in cell differentiation contribute to the development of preneoplastic and neoplastic lesions
- Establish new animal models of pancreatic cancer focusing on the early events involved in tumour development and the role of the stroma
Bladder cancer:
- Identify the genes/pathways involved in the development of bladder cancer subtypes and the mechanisms involved therein
- Establish molecular markers of recurrence/progression and response to therapy
- Develop an integrative 'omics' approach to understanding tumour development/progression